Hardeman House, built in 1892, is listed on the National Register of Historic Places and is situated on Old Washington Square, a "center" in Nacogdoches much older than the town square. The Caddo Indians established the area as a ceremonial site between 1250 and 1450 A.D. One of their mortuary mounds remains today on Mound St. Another mound located on the property of the Hardeman House was excavated in the 1930's.

In 1845, Haden Edwards, Charles S. Taylor and J.R. Arnold promised 2.5 acres to the city to erect a building for the Nacogdoches University which was chartered at the time. Built in 1858, the modified Grecian structure was the first nonsectarian university established during the Republic of Texas, and the only original building chartered by the Republic still standing.

Robert Lee Hardeman, a descendent of an early pioneering family of Texas, built his one-story home at the corner of Church and Arnold Streets in 1892. in 1912, Hardeman commissioned prominent architect Dietrich Rulfs to enlarge the house adding the second story, a wrap-around gallery, new siding and interior. Mr. Rulfs also designed and built 15 other turn-of-the-century homes and churches located in the neighborhood.

Lee and Ida Hardeman had three children; Homer, Gladys and Curtis. Gladys never married and lived in the home until just prior to her death in 1980.